BizSugar.com › Technology › Avoid These Email Address Before Hitting Send

Those recipients which has stopped opening your emails, initially they shouldn't be erase from your list immediately. Because they can be ask for feedback which gives them opportunity to change their opt-in settings, but yes after your re-engagement attempts if some of the recipients are still disengaged subscribers, then you should proactively erase them from your list before they damage your reputation and mark you as SPAM.